Pervasive Selection against MicroRNA Target Sites in Human Populations
نویسندگان
چکیده
منابع مشابه
Selection Against Maternal microRNA Target Sites in Maternal Transcripts
In animals, before the zygotic genome is expressed, the egg already contains gene products deposited by the mother. These maternal products are crucial during the initial steps of development. In Drosophila melanogaster, a large number of maternal products are found in the oocyte, some of which are indispensable. Many of these products are RNA molecules, such as gene transcripts and ribosomal R...
متن کاملHuman polymorphism at microRNAs and microRNA target sites.
MicroRNAs (miRNAs) function as endogenous translational repressors of protein-coding genes in animals by binding to target sites in the 3' UTRs of mRNAs. Because a single nucleotide change in the sequence of a target site can affect miRNA regulation, naturally occurring SNPs in target sites are candidates for functional variation that may be of interest for biomedical applications and evolution...
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MicroRNAs (miRNAs) regulate genes post transcription by pairing with messenger RNA (mRNA). Variants such as single nucleotide polymorphisms (SNPs) in miRNA regulatory regions might result in altered protein levels and disease. Genome-wide association studies (GWAS) aim at identifying genomic regions that contain variants associated with disease, but lack tools for finding causative variants. We...
متن کاملMaternal microRNAs in Drosophila eggs: selection against target sites in maternal protein-coding transcripts
In animals, before the zygotic genome is expressed, the egg already contains gene products deposited by the mother. These maternal products are crucial during the initial steps of development. In Drosophila melanogaster a large number of maternal products are found in the oocyte, some of which are indispensable. Many of these products are RNA molecules, such as gene transcripts and ribosomal RN...
متن کاملHypothesis: RNA editing of microRNA target sites in humans?
Adenosine (A) to inosine (I) RNA editing occurs widely in the human transcriptome, and a large proportion of editing sites are within untranslated regions (UTRs). MicroRNAs (miRNAs), an abundant class of regulatory genes, specify the expression of a large number of target genes by pairing to their 3' UTRs. To study the interplay between these two post-transcriptional events, we developed a comp...
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ژورنال
عنوان ژورنال: Molecular Biology and Evolution
سال: 2020
ISSN: 0737-4038,1537-1719
DOI: 10.1093/molbev/msaa155